Understanding the Molecular Mechanisms of Cellular Motility

Our goal is to understand the mechanisms of cell motility. We have continued to focus on actin which is one of the most important proteins required for the force generation in a migrating cell. Actin is a highly conserved protein and one of the most abundant in eukaryotic cells. It is becoming clear that actin has a highly polymorphic structure and it exhibits cooperative behavior. Currently, we are mainly focused on research involving structural polymorphism and functional differentiation of actin filaments.